http://health.groups.yahoo.com/group/dysferlin/ Dysferlin Deficiency Wed, 18 Nov 2009 03:16:24 GMT MATHEW anas http://health.groups.yahoo.com/group/dysferlin/message/587 http://health.groups.yahoo.com/group/dysferlin/message/587 to my understanding (no scientist here), the delivery method is different for different versions of the the follistatin gene. i rather use the soluble fusion Tue, 17 Nov 2009 18:54:56 GMT Thayer, Joshua http://health.groups.yahoo.com/group/dysferlin/message/586 http://health.groups.yahoo.com/group/dysferlin/message/586 Hi Matt, Thank you for the link to Acceleron. Looks promising, but it is a totally different compound than the Myo-29 study that was conducted by Wyeth, which Tue, 17 Nov 2009 16:59:49 GMT MATHEW anas http://health.groups.yahoo.com/group/dysferlin/message/585 http://health.groups.yahoo.com/group/dysferlin/message/585 hey Josh. dont now if you know that accelleron already compleeted phase 1 study for the same or maybe beefed up compounds, as the mda grantees do. that's in Tue, 17 Nov 2009 16:48:55 GMT baw1064 http://health.groups.yahoo.com/group/dysferlin/message/584 http://health.groups.yahoo.com/group/dysferlin/message/584 A brief description on myostatin, etc. to try to make the discussion understandable to everyone. Myostatin is a protein that is a negative regulator of muscle Tue, 17 Nov 2009 16:12:17 GMT Thayer, Joshua http://health.groups.yahoo.com/group/dysferlin/message/583 http://health.groups.yahoo.com/group/dysferlin/message/583 Matt, Thank you for the Science Daily link. That is very interesting and encouraging in my opinion. Could you explain why you consider what Dr. Mendell is Tue, 17 Nov 2009 16:00:36 GMT Thayer, Joshua http://health.groups.yahoo.com/group/dysferlin/message/582 http://health.groups.yahoo.com/group/dysferlin/message/582 The video is inspirational. Thank you. So, who is complaining Matt? ________________________________ From: dysferlin@yahoogroups.com Tue, 17 Nov 2009 15:55:59 GMT MATHEW anas http://health.groups.yahoo.com/group/dysferlin/message/581 http://health.groups.yahoo.com/group/dysferlin/message/581 to whom it may concern.. and its Dr. Mendell not cambell. my mistake To: dysferlin@yahoogroups.com From: jthayer@... Date: Tue, 17 Nov 2009 10:44:48 Tue, 17 Nov 2009 15:45:00 GMT Thayer, Joshua http://health.groups.yahoo.com/group/dysferlin/message/580 http://health.groups.yahoo.com/group/dysferlin/message/580 Matt, Whom exactly are you addressing? Me? Brad? The group? Who is complaining? About what? I'll email you off line once I look at the links. Josh Tue, 17 Nov 2009 14:57:05 GMT MATHEW anas http://health.groups.yahoo.com/group/dysferlin/message/579 http://health.groups.yahoo.com/group/dysferlin/message/579 don't want to discount the abilities and the efforts of dr Campbells lab, but it seems to me like reinventing the wheel here? maybe waste of money? Tue, 17 Nov 2009 05:57:02 GMT baw1064 http://health.groups.yahoo.com/group/dysferlin/message/578 http://health.groups.yahoo.com/group/dysferlin/message/578 The publication reference is Stem Cells. 2004;22(6):981-93. Human umbilical cord blood cells differentiate into muscle in sjl muscular dystrophy mice. Kong KY, Mon, 16 Nov 2009 16:59:10 GMT Thayer, Joshua http://health.groups.yahoo.com/group/dysferlin/message/577 http://health.groups.yahoo.com/group/dysferlin/message/577 Hi Matt, I will check to see if the cord blood study results were published by Dr. Brown's lab at M.G.H.. I believe so. I'll look into it and send you a link Mon, 16 Nov 2009 16:19:50 GMT MATHEW anas http://health.groups.yahoo.com/group/dysferlin/message/576 http://health.groups.yahoo.com/group/dysferlin/message/576 I congratulate you and thank you for your efforts towards a treatment. i dint realize that you were involved in to that extend in trying to help. i think of Mon, 16 Nov 2009 15:36:52 GMT Thayer, Joshua http://health.groups.yahoo.com/group/dysferlin/message/575 http://health.groups.yahoo.com/group/dysferlin/message/575 Matt, As I understand it, there may still be a potential for Myoblasts. I know that at least one doctor up in Quebec designed studies back in the 1990s that Mon, 16 Nov 2009 13:29:58 GMT MATHEW anas http://health.groups.yahoo.com/group/dysferlin/message/574 http://health.groups.yahoo.com/group/dysferlin/message/574 by any means, i don't want to discourage people to come forward and participate to any approach that facilitates a potential therapy or treatment. my Mon, 16 Nov 2009 05:04:55 GMT baw1064 http://health.groups.yahoo.com/group/dysferlin/message/573 http://health.groups.yahoo.com/group/dysferlin/message/573 Josh is very knowledgable about the economics and approval process. I'll just add a little bit to his post. Besides "dysferlin-specific custom therapies" a